In Vitro Toxicology Systems brings together important issues and considerations
needed in order to develop a workable, reliable, integrated testing strategy for
the replacement of animals in toxicity testing regimes. This thorough volume
includes sections on in vitro models for systemic organ toxicity, neurotoxicity,
sensory organs, immunotoxicity and reproductive toxicity and addresses how stem
cells may be used going forward. The book also tackles difficult areas of
toxicology such as carcinogenicity and nanotoxicology, with additional chapters
dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book
also addresses biological processes such as stress response pathways and
mechanistic biomarkers and how these can be uncovered and measured