Over the past 15 years researchers have made enormous gains in understanding the
various aspects of tyrosine phosphoprotein phosphatases (PTPases), with
particularly important insights into their molecular biology, biochemistry, and
role in cellular physiology. This new edition of TyrosinePhosphoprotein
Phosphatases provides a practical and accessible guide to this major family of
proteins. Topics discussed include the sequence, structure, and biochemical
properties of PTPases, regulation of PTPase expression, substrate preferences
and catalytic mechanisms, physiology, covalent modification, modification by
chemical agents and proteolysis, and interactions with other proteins, peptides,
and macromolecules. Featuring comprehensive coverage of the subject, including
an extensive bibliography, this volume will provide an important resource for
researchers and graduate