The number of available synthetic methods can be overwhelming. In order to
create novel motifs and templates which confer new and potentially valuable
drug-like properties, it is important to know which synthetic methodologies will
give the best results. This two-volume set of books provides both academic and
industrial perspectives on key reactions giving the reader an excellent overview
of the techniques used in modern synthesis. Reaction types are conveniently
framed in the context of their value to industry and the challenges and
limitations of methodologies are discussed with relevant illustrative examples.
Moreover, key opportunities in expanding chemical space are presented, including
the increasingly important syntheses that introduce three-dimensional