This volume includes information on recent advances in five important areas: an
account of inhibitors of the caspase family of proteolytic enzymes that
represent a new class of anti-inflammatory and antiapoptotic agents of potential
value in rheumatoid arthritis; and a survey of semi-synthetic and totally
synthetic antibiotics and anti-HIV agents and their sites of interaction; the
development of inhibitors of the intracellular enzyme acyl-CoA: cholesterol
O-acyltransferase (ACAT) for the treatment of hypercholesterolemia; a
description of recent progress in growth hormone secretagogues, with the focus
on strategies to improve oral bioavailability and duration of action; and
information on inhibition of the proteolytic enzyme, hepatitis C protease
N-3(NS3), (required for vital