Polyamines are ubiquitous molecules that are involved in a number of important
cellular processes. Aberrations in their function or metabolism play a role in
diseases such as cancer and parasitic infection. A number of validated drug
targets have been identified, including enzymes in the polyamine biosynthetic
and catabolic pathways and the S-adenosylmethionine synthetic and salvage
pathways. Polyamine Drug Discovery is the first comprehensive volume to cover
all aspects of the design and development of potential therapeutics targeting
polyamine metabolism. The book details research progress from 1975 to the
present date and discusses the design and use of polyamine metabolism inhibitors
as therapeutic agents. Various polyamine-containing drugs are described