This book offers pertinent basic science information on strategies used for the
rational design and discovery of novel anticancer agents, and, in addition,
translational studies involving clinical trial design and execution with these
novel, mostly cytostatic agents. This book covers basic science strategies that
are being used in drug discovery and preclinical evaluation focused on novel
molecular targets, as well as clinical trial methodology including clinical
pharmacokinetics and imaging to address issues of efficacy evaluation of the
new, relatively non-cytotoxic anticancer agents.
At present, there is no book that provides such an integration of basic and
clinical studies of novel anticancer agents, covering both drug discovery and
translational