Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug
attrition and the safety of xenobiotics are critically important. This book
presents a comprehensive treatise on the current issues and challenges facing
drug metabolism and pharmacokinetics. Readers will find a thorough exploration
of their predictive role in impacting drug discovery and development and in
improving the success rate and safety assessment of pharmaceuticals and
industrial or occupational chemicals. Chapters not only focus on the current
state of art, with distinct examples, but on future needs and approaches likely
to improve our prediction of potential human risk. Discussions of critical
properties that are determinants of a compound's metabolic and pharmacokinetic
fate