For more than seventy years evidence has accumulated documenting the existence
of a bi-directional communication network between growth hormone and the immune
system. In the past twenty years there has been a tremendous proliferation of
information detailing the workings of the growth hormone and insulin-like growth
factor axis. A multitude of growth factors and binding proteins have been
identified. More and more evidence supporting the important role of the growth
hormone IGF network in the well functioning of the normal immune system has been
documented. Clearly the challenge today is not to prove, but to understand, the
neuroimmune regulatory role of GLH in its entire complexity.
The ultimate