Multivariate (MV) analysis of the multi-component analytical profiles of
carefully collected biofluid and/or tissue biopsy specimens provides a
'fingerprint' of their biomolecular/metabolic status and hence, when correctly
applied, much valuable information regarding disease indicators, disease strata
and sub-strata, and disease activities. These techniques serve as powerful tools
for clinical and toxicological research, including drug development, early
disease detection, and the stratification of patients into disease or
treatment/treatment response sub-classes. They also serve as an extremely
valuable means of providing pre-clinical biomarkers of the therapeutic and/or
toxicological capacity of newly-developed drugs. Currently, the most informative
techniques utilised in such research investigations are high-resolution
biomedical Nuclear Magnetic Resonance (NMR) analysis, and both