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Book Summary
Hands-on experts from laboratories around the world describe in step-by-step
detail their cutting-edge methods for developing and applying these powerful
proteins. The conjugates created by these researchers contain entire monoclonal
antibodies, single chain antibody fragments, and cytokines as their carrier
ligands. Their toxic portion can include such conventional chemotherapeutics as
doxirubicin, such ribosome-inactivating proteins the ricin A chain or saporin,
or such bacterial toxins as diphtheria toxin. Also described are a variety of
applications that demonstrate the versatility of these agents, including the
treatment of primary malignant brain tumors, the generation of selective brain
lesions to localize critical functions, and the targeting of the AIDS virus.
Authoritative and highly
Hands-on experts from laboratories around the world describe in step-by-step
detail their cutting-edge methods for developing and applying these powerful
proteins. The conjugates created by these researchers contain entire monoclonal
antibodies, single chain antibody fragments, and cytokines as their carrier
ligands. Their toxic portion can include such conventional chemotherapeutics as
doxirubicin, such ribosome-inactivating proteins the ricin A chain or saporin,
or such bacterial toxins as diphtheria toxin. Also described are a variety of
applications that demonstrate the versatility of these agents, including the
treatment of primary malignant brain tumors, the generation of selective brain
lesions to localize critical functions, and the targeting of the AIDS virus.
Authoritative and highly