This practical guide for physicians and other health care professionals
discusses the impact of fatigue on the individual with MS, the potential
etiologies underlying MS-related fatigue, its work up and diagnosis, and
pharmacologic and nonpharmacologic management strategies. Fatigue is perhaps the
single most prevalent and disabling symptom of the multiple sclerosis, and
limits patients' activity more than any other MS symptom. The identification of
fatigue as a distinct clinical entity requires both art and science, and most of
all, a willingness and ability to listen carefully to patients and their
families. The physician's ability to obtain a comprehensive history requires a
full understanding of the circumstances in which