A benchmark synthesis of the current state of the science and clinical practice
of the ketogenic diet. On the basic science side, the authors review what is
known about the basic biochemical mechanisms of action of the KD at the
molecular level, spelling out in detail its complex interactions with nutrient
components, neurodevelopment, brain biochemistry, and physiology. They also
examine the effects of the KD on the metabolism of fats, amino acids, and
carbohydrates in the central nervous system at both the macro and cellular
levels. On the clinical side, physicians, dietitians, and nurses provide a full
range of information concerning the treatment of seizures with KD,