B. Paul Morgan and a team of expert laboratorians present a comprehensive set of
readily reproducible methods to study this critical system. These cutting-edge
techniques are suitable both for the basic scientist interested in understanding
complement's mechanisms of activation and for the clinical scientist wishing to
quantify its activation, and range from the purification of its components to
generating complement-deficient mice by gene deletion. Additional techniques
presented include procedures for the analysis of its function, for the study of
its regulators, for detection of its activation in vivo, and for the
identification of its autoantibodies. Comprehensive and cutting-edge, Complement
Methods and Protocols offers today's basic and clinical investigators